Minimally important differences and severity thresholds are estimated for the PROMIS depression scales from three randomized clinical trials

Innovations in Stroke: The Use of PROMIS and NeuroQoL Scales in Clinical Stroke Trials.

Are gender differences important for the clinical effects of antidepressants?

OBJECTIVE Gender differences in antidepressant treatment response, side effects, dropout rates, and plasma concentrations were examined in patients with major and predominantly melancholic depression. METHOD The study included a subgroup of 292 inpatients (96 men, 196 women) from three Danish double-blind, randomized, controlled trials. All patients completed a 5-week treatment period and ful...

Determining minimally important score differences in scales of the Copenhagen Psychosocial Questionnaire.

AIM To determine minimally important differences (MIDs) for scales in the first version of the Copenhagen Psychosocial Questionnaire (COPSOQ). METHODS Data were taken from two separate studies: a national population survey (N = 1062), and an intervention study at 14 workplaces (N = 1505). On the basis of the population survey, the MID for each COPSOQ scale was calculated as one-half of a stan...

Are more responsive depression scales really superior depression scales?

In contemporary clinical practice and research, many different instruments are used to measure depression severity. Santor et al. [1] identified no fewer than 280 scales developed in the last century, many of which are still in use. The responsiveness of these various depression scales to treatmentdand the comparison of responsiveness among scalesdhas become an important research topic. Respons...

Homeopathy for childhood diarrhea: combined results and metaanalysis from three randomized, controlled clinical trials.

BACKGROUND Previous studies have shown a positive treatment effect of individualized homeopathic treatment for acute childhood diarrhea, but sample sizes were small and results were just at or near the level of statistical significance. Because all three studies followed the same basic study design, the combined data from these three studies were analyzed to obtain greater statistical power. ...